BEM1 — Neurospora crassa

Summary

NCU06593, also known as NcBEM1 or NcSCD2, encodes a protein with SH3, PX, and PB1 domains, and is associated with kinase activity, phosphoinositide binding, and protein binding, bridging. This Neurospora crassa gene on chromosome 4 is linked to cell-cell signaling, regulation of conjugation with cellular fusion, upregulation of mating projection assembly, regulation of cell polarity, cell polarization, and cell communication. It localizes to the enzyme complex, cortical dynamic polarity patch, mating projection tip, plasma membrane at the cell tip, cell division site, cytoplasm, cytosol, and nucleus. Phenotypic associations include delayed nuclear fusion during mating, absent bipolar budding, decreased redox state, abnormal pheromone production, decreased cytokinesis, decreased intracellular transport, premature G2/M transition, absent vacuolar morphology, increased shmoo formation, decreased spore germination, absent cell fusion, absent fermentative growth, and increased mating efficiency. Related genes in other species link the family to Cdc42 GTPase complex localization.