CAG1 — Neurospora crassa

Summary

NCU06493, also known as CAG1 or gna-1 on Neurospora crassa chromosome 3, encodes a fungal G-protein alpha subunit (GproteinA_insert, Gprotein_alpha_su domains) with GTPase activity and guanyl nucleotide, G protein-coupled receptor, and G-protein beta/gamma-subunit complex binding. This gene is associated with regulation of adenylyl cyclase activity, cAMP metabolism, GPCR signaling, carbon catabolite repression, sexual reproduction (syngamy, sporocarp development), asexual sporulation (conidium formation), appressorium formation, pheromone response, and regulation of secondary metabolite biosynthesis (sterigmatocystin, penicillin). It localizes to the heterotrimeric G-protein complex, cytoplasm, and mitochondrial outer membrane. Phenotypic associations include absent mating efficiency, abnormal mating response, abnormal pheromone sensitivity, increased pheromone production, delayed sporulation, increased pexophagy, and altered cell cycle progression. Studies of related genes in other species link the family to pathogenicity and virulence traits.