puf3 — Neurospora crassa

Summary

NCU06511 (puf3) on Neurospora crassa chromosome 3 encodes a PUM-HD domain-containing protein with exoribonuclease activator activity, CCR4-NOT complex binding, and mRNA 3′-UTR AU-rich region binding. It is associated with positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, deadenylation-dependent mRNA decay, and posttranscriptional regulation of gene expression. The gene is linked to the electron transport chain, TCA cycle, and meiotic cell cycle. Its product localises to P bodies, stress granules, the mitochondrial outer membrane, cytoplasm, and cytosol.