MET6 — Neurospora crassa

Summary

NCU06512 (MET6, met-8) on Neurospora crassa chromosome 3 encodes a cobalamin-independent methionine synthase (EC 2.1.1.14) with zinc-binding activity, belonging to the Cbl-indep_Met_Synth_N and Met_Synth_C/arc domain families. The gene is associated with methionine metabolism and de novo L-methionine biosynthesis, as well as perturbation of host immune response, chromatin silencing, cell-cell adhesion, DNA replication, methylation, and cellular response to heat. The product localizes to the cytosol, nucleus, hyphal and fungal-type cell walls, and fungal biofilm matrix. Phenotypic associations include altered prion inheritance, increased replicative and chronological lifespan, increased oxidative stress resistance, decreased thermotolerance and acid pH resistance, abnormal fermentative and respiratory metabolism, increased telomere length, and auxotrophy. Related genes in other species link the family to methionine biosynthesis.