PPA3 — Neurospora crassa

Summary

NCU06563 (PPA3, also known as pp2A) on Neurospora crassa chromosome 4 encodes a protein with protein phosphatase activity and protein serine/threonine phosphatase activity (EC 3.1.3.16), belonging to the PPA2-like, Ser/Thr-specific protein phosphatase, calcineurin-like phosphoprotein phosphatase, and metallo-dependent protein phosphatase-like families. The gene is associated with protein dephosphorylation, negative regulation of mitophagy, regulation of TORC1 signaling, cell-cell fusion, glycogen metabolism, and regulation of cell shape. It localizes to the PP2A complex, protein phosphatase 4 complex, nuclear periphery, mitochondrial outer membrane, mitotic spindle pole body, and chromatin. Phenotypic associations include abnormal pheromone sensitivity, decreased resistance to chemicals and ionic stress, altered cell cycle progression (G1/S transition, S phase, G2 phase), increased mitophagy, decreased pexophagy and reticulophagy, abnormal mitochondrial genome maintenance, and decreased apoptosis. Studies of related genes in other species link the family to reduced virulence and acid sensitivity.