IRC5 — Neurospora crassa

Summary

NcIRC5 (NCU06306) on Neurospora crassa chromosome 4 encodes a protein with ATP-dependent H2AZ histone chaperone activity, nucleosomal DNA binding, histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, ATP-dependent chromatin remodeler activity, centromere binding, structural molecule activity, nucleosome binding, helicase activity, chromatin adaptor activity, histone binding, ssDNA binding, and chromatin binding. It belongs to the SNF2/RAD54-like family and is a component of the INO80, SWI-SNF, SWR-C, and PBAF complexes. The gene is associated with epigenetic regulation of gene expression, chromatin silencing, heterochromatin boundary formation, rDNA heterochromatin assembly, DNA condensation, recombinational repair, transcription by RNA polymerase II, and cellular responses to copper and pheromones. It has been linked to chlamydospore formation, filamentous growth in response to biotic stimuli, and cell cycle progression through G1/S and G2 phases. Related genes in other species connect it to DNA repair and chromatin remodeling functions.