LAC12 — Neurospora crassa

Summary

NCU05853 (LAC12) on Neurospora crassa chromosome 7 encodes a major facilitator superfamily (MFS) sugar transporter. The gene product exhibits myo-inositol:proton symporter activity, D-glucose transmembrane transporter activity, proton:sugar symporter activity, and vitamin Bh transporter activity. It is associated with carbohydrate transport, glucose transmembrane transport, myo-inositol import into the cell, and vitamin Bh transport. LAC12 is associated with filamentous growth, particularly in response to heat and neutral pH, as well as cellular responses to heat, neutral pH, and xenobiotic stimulus. The protein localizes to the plasma membrane, membrane, and extracellular vesicles. Studies of related genes in other species link the family to myo-inositol transport and fungal pathogenesis.