gaaC — Neurospora crassa

Summary

NCU05977 (gaaC) on Neurospora crassa chromosome 6 encodes a protein with DapA-like and aldolase_TIM domains that exhibits 2-keto-4-hydroxyglutarate aldolase activity, (4S)-4-hydroxy-2-oxoglutarate aldolase activity, dihydrodipicolinate synthase activity, aldehyde-lyase activity, lyase activity, DNA-binding transcription factor activity, and zinc binding. The gene is associated with nitrogen catabolite activation of transcription from RNA polymerase II promoters, D-galacturonate breakdown, fermentation, and DNA-dependent transcription. Its product localizes to the nucleus. Studies of related genes in other species link the family to dihydrodipicolinate synthase and 4.1.3.16/4.1.2.54 enzyme activities, though these associations are not established for NCU05977 itself.