CWH43 — Neurospora crassa

Summary

NCU05895 (CWH43) in Neurospora crassa chromosome 7 encodes a protein with domains characteristic of GPI-anchor lipid remodelers, including PGAP2IP and CWH43_N domains, and belongs to the endo/exonuclease/phosphatase superfamily. The gene is associated with GPI anchor anabolism, protein processing, fungal-type cell wall organization, fermentation, ribosome biogenesis, and rRNA processing. The product localizes to the nuclear envelope, ER membrane, ER, plasma membrane, and membrane. Phenotypic associations include abnormal cell wall and plasma membrane morphology, increased necrotic cell death and cell death, decreased pheromone sensitivity, mating efficiency, nutrient uptake, growth, cytokinesis, protein secretion, and transport, as well as altered cell cycle progression, mitotic recombination, and autophagy. Related genes in other species link the family to acid sensitivity.