FLC1 — Neurospora crassa

Summary

NCU05785 (FLC1) in Neurospora crassa encodes a stretch-activated, monoatomic cation-selective calcium channel with TRP_N, TRP_C and TRP_Flc/Pkd2-like domains. This transmembrane transporter is associated with calcium ion import, calcineurin-mediated signaling, MAPK cascade, cellular HOG response, and regulation of cell wall (1→3)-β-D-glucan biosynthesis. It is associated with FAD transport, cellular water homeostasis, fungal-type cell wall biogenesis, and membrane transport. The protein localizes to the plasma membrane at cell tips, cleavage furrow, division septum, Golgi and ER membranes. Phenotypic associations include increased lifespan and hyperosmotic stress resistance, decreased cytokinesis, spore germination and ionic stress resistance, abnormal vegetative growth and sporulation, increased chitin deposition and biofilm formation, and arrested G1 cell cycle progression. Studies of related genes in other species link the family to turgor pressure and acid sensitivity.