FPHA — Neurospora crassa

Summary

NCU05790 (FPHA, phy-2) on Neurospora crassa chromosome 7 encodes a phytochrome with histidine kinase, phosphorelay sensor kinase, and response regulator activities, and is associated with osmosensor and peroxide sensor activities. The protein localizes to the plasma membrane, cell tip, and division site, and is associated with detection of visible light, osmolarity sensing via a two-component system, activation of the p38 cascade, regulation of conidium formation and sexual reproduction, ascospore formation, filamentous growth, fungal-type cell wall biogenesis, and cellular responses to farnesol and reactive oxygen species. It is also linked to downregulation of phagocytosis and calcium-independent cell-cell adhesion, as well as regulation of biofilm formation. Related genes in other species are linked to reduced virulence and loss of pathogenicity.