PREB — Neurospora crassa

Summary

NCU05758 (PREB, pre-2) on Neurospora crassa chromosome 7 encodes a mating-type factor pheromone receptor, a GPCR of the STE2 family. The gene is associated with detection of pheromone, sexual sporulation, chemotropism, sexual reproduction, mating, meiosis, signal transduction, and membrane transport. It localises to the GPCR homodimer. Phenotypic associations include absent mating efficiency and cell fusion, abnormal mating response, sterile phenotype, absent or decreased pheromone sensitivity, altered pheromone production, increased recovery from pheromone-induced cell cycle arrest, decreased budding rate, increased endocytosis, and abnormal vesicle distribution. The gene is also linked to oxidative stress response.