AMO1 — Neurospora crassa

Summary

NCU05518 (AMO1) on Neurospora crassa chromosome 6 encodes a copper-containing amine oxidase, classified as EC 1.4.3.21 with primary methylamine oxidase and histamine oxidase activities, and binds copper and quinone. The protein is associated with amine metabolism and breakdown, cellular copper ion homeostasis, and cellular detoxification. It localises to the ascospore-type prospore, peroxisome, plasma membrane, cytoplasm, and cytosol. Studies of related genes in other species link the family to EC 1.4.3.22 activity, but this is not established for NcAMO1.