SAM50 — Neurospora crassa

Summary

NCU05593, designated SAM50 or tob55 in Neurospora crassa on chromosome 6, encodes a D15-like domain-containing protein that is a component of the mitochondrial outer membrane SAM complex. The gene is associated with mitochondrial outer membrane protein import and structural organization. It has been linked to numerous phenotypes including abnormal mitochondrial distribution and genome maintenance, altered respiratory metabolism, increased cell death, arrested vegetative growth, absent spore germination, and abnormal redox state, endomembrane system morphology, and peroxisomal morphology. Associations also include decreased mitophagy, decreased survival rate in stationary phase, and increased duration of cell cycle progression in G1 phase. Studies of related genes in other species connect the SAM50 family to mitochondrial transport and protein import.