ABCA — Neurospora crassa

Summary

NCU05591 (ABCA, NcABCA) on Neurospora crassa chromosome 6 encodes an ABC transporter with ATP hydrolase activity and ATP binding, belonging to the ABCG_PDR family. The gene is associated with ceramide anabolism, ergosterol metabolism, ergosterol anabolism, phospholipid anabolism, chitin anabolism, zearalenone biosynthetic process, response to toxic substance, xenobiotic detoxification by transmembrane export across the plasma membrane, detoxification, hypersensitivity, and homeostasis. It localises to the vacuolar membrane, plasmalemma and membrane. Phenotypic associations include abnormal small molecule transport, decreased vacuolar distribution, increased vacuolar transport, increased sporulation rate, decreased cell death rate, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, and abnormal respiratory metabolism. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance, protein content, phosphate content, and oxidative stress response.