pmb — Neurospora crassa

Summary

NCU05168 (pmb) on Neurospora crassa chromosome 4 encodes a basic amino acid permease with L-arginine, L-lysine, L-histidine and L-proline transmembrane transporter activities and amino acid binding capacity. The gene is associated with amino acid membrane transport, including L-arginine transmembrane transport, proline import, basic amino acid transport and SAM transport. The encoded protein localises to the plasma membrane, eisosome, extracellular vesicle, Golgi complex and ER. Phenotypic associations link pmb to abnormal nitrogen source utilisation, increased polyploidy and aneuploidy, decreased nutrient uptake, altered cell cycle progression, decreased apoptosis, increased freeze-thaw resistance, decreased cold sensitivity, increased pseudohyphal growth, abnormal plasma membrane morphology, and defects in endocytosis, ribophagy, vacuolar transport, protein distribution, nuclear fusion and spindle pole body positioning. Studies of related genes in other species connect the family to biofilm formation, flocculation, stress resistance and virulence.