ENA1 — Neurospora crassa

Summary

NCU05046 (ENA1, ena-1) on Neurospora crassa chromosome 6 encodes a P-type ATPase of subfamily IID with potassium:proton and sodium transporter activity (EC 7.2.2.3). The gene is associated with potassium and sodium ion export from the cell, cellular pH reduction, and calcium, manganese and proton membrane transport. It is linked to cellular ion homeostasis, macroautophagy, and the response to unfolded protein. The product localises to the plasma membrane, cell tip, vacuolar membrane, Golgi and ER membranes. Phenotypic associations include altered cell cycle progression, decreased endocytosis, increased freeze-thaw and ionic stress resistance, increased respiratory metabolism, and absent nutrient uptake, meiosis and desiccation resistance. Studies of related genes in other species link the family to sodium concentration, potassium content and salt tolerance traits.