AOX — Neurospora crassa

Summary

NCU04874 (AOX, NcAOX) encodes an alternative oxidase (AOX_sf family) with alternative oxidase activity and metal binding, localised to the mitochondrial inner membrane and respirasome. This gene is associated with alternative respiration, the electron transport chain, gluconeogenesis, fermentation, secondary metabolism, detoxification, and hypersensitivity. It is also linked to sexual reproduction and syngamy, as well as heterotrophy. Studies of related genes in other species connect the family to oxidative stress response and interactions with Verticillium dahliae and Fusarium oxysporum.