SNF1 — Neurospora crassa

Summary

NCU04566, designated NcSNF1 (also known as NcSSP2, SSP2, prk-10) on Neurospora crassa chromosome 5, encodes a serine/threonine protein kinase with protein kinase A activity, ATP binding, and phospholipid binding. The product contains SNF1_UBA, AMPK_C, and KA1/Ssp2_C domains. This gene is associated with carbon catabolite repression, glycogen metabolism, mycose catabolism, and upregulation of gluconeogenesis and macroautophagy. It is linked to positive regulation of the mitotic-to-meiotic cell cycle switch, negative regulation of cytoplasmic translation and inositol phosphate biosynthesis, and regulation of invasive growth in response to glucose limitation. Localization evidence connects the product to the nucleotide-activated protein kinase complex, perinuclear space, septin rings, cellular bud neck, and vacuolar membrane. Studies of related genes in other species link this gene family to turgor pressure, loss of pathogenicity, and lethal phenotypes.