SRBA — Neurospora crassa

Summary

NCU04731 (SRBA, also known as sah-2) on Neurospora crassa chromosome 6 encodes a basic helix-loop-helix (bHLH) transcription activator with SRE-binding activity, containing a Sre1_C domain and belonging to the regulatory transcription factor family. The gene product is associated with SREBP signalling, sterol and ergosterol metabolism and homeostasis, cellular responses to hypoxia, heat, copper, neutral pH, and iron ion homeostasis. It is linked to the regulation of filamentous growth in response to chemical, biotic, and pH stimuli, as well as biological processes involved in symbiotic interaction. The protein localises to the Sre1-Scp1 complex, endoplasmic reticulum membrane, nuclear envelope, Golgi membrane, chromatin, cytoplasm, and nucleus. Related genes in other species are linked to reduced virulence.