qutR — Neurospora crassa

Summary

NCU04358 (qutR) on Neurospora crassa chromosome 4 encodes a protein with shikimate kinase, 3-dehydroquinate synthase, shikimate 3-dehydrogenase (NADP+), 3-phosphoshikimate 1-carboxyvinyltransferase, and 3-dehydroquinate dehydratase activities, and also binds DNA, ATP, and metals. The gene is associated with the shikimate pathway, aromatic amino acid biosynthesis and transport, quinate breakdown, monocarboxylic acid metabolism, heterotrophy, and negative regulation of transcription by RNA polymerase II, as well as cellular response to xenobiotic stimulus. Its product localises to the cytoplasm. Related genes in other species are linked to a repressor function in quinate metabolism and, in some species, to reduced virulence.