EGT1 — Neurospora crassa

Summary

NCU04343 (EGT1, egt-1) on Neurospora crassa chromosome 4 encodes a hercynylcysteine S-oxide synthase (EC 1.21.3.10) with histidine methyltransferase activity (EC 2.1.1.44), possessing DinB-like, SUMF, and SAM-dependent methyltransferase domains. The gene is associated with ergothioneine and selenoneine biosynthesis, ergot alkaloid and fumigaclavine C anabolism, indole alkaloid metabolism, nitric oxide storage, amino acid biosynthesis, hyphal growth, fermentation, the meiotic cell cycle, and methylation. It is linked to genetic transfer and protein homodimerization activity, calcium ion binding, and metal binding, with localization to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species connect the family to additional methyltransferase functions.