tom70 — Neurospora crassa

Summary

NCU04245 (tom70) on Neurospora crassa chromosome 5 encodes a protein with tetratricopeptide repeat (TPR) domains, possessing mitochondrion targeting sequence binding, protein translocase, membrane insertase, Hsp90 binding, Hsp70 protein binding, and protein serine/threonine phosphatase activities. It is a component of the TOM and TRC complexes, localizing to the mitochondrial outer membrane, mitochondria, membrane, cytosol, and nucleus. The gene is associated with mitochondrial protein import, including inner membrane and matrix protein import, posttranslational protein targeting to the ER membrane, type II transmembrane protein insertion into the ER membrane, mitochondrial distribution and biogenesis, electron transport chain, intracellular protein transport, and response to heat. Studies of related genes in other species link the family to germination rate and oxidative stress response.