SLY1 — Neurospora crassa

Summary

NCU04252 (SLY1, NcSLY1) on Neurospora crassa chromosome 5 encodes a SNARE docking complex subunit containing Sec1-like domains, with molecular function in syntaxin binding. The gene is associated with positive regulation of SNARE complex assembly, regulation of Ras protein signal transduction, vesicle fusion with the Golgi apparatus, karyogamy, and multiple transport processes including ER-to-Golgi and cis-Golgi-to-rough ER transport. The product localises to Golgi and ER membranes, COPII-coated vesicles, and the cytosol. Phenotypic associations link SLY1 to abnormal sporulation efficiency, increased virulence, decreased cell cycle progression, delayed vacuolar transport, decreased polyploidy, premature apoptosis, and altered protein transport, secretion, and distribution. Related genes in other species connect the family to interactions with DSL1, VTI1, and YKT6.