NDK1 — Neurospora crassa

Summary

NCU04202, designated NDK1 on Neurospora crassa chromosome 5, encodes a nucleoside diphosphate kinase (EC 2.7.4.6) with ATP-binding and metal-binding activities. The gene is associated with nucleoside triphosphate anabolism, including UTP, CTP, and GTP biosynthesis, as well as protoperithecium formation, conidia formation, anisotropic cell growth, morphogenesis, signal transduction, response to heat, and DNA damage response. NDK1 localises to the cytosol, nucleus, mitochondrial envelope lumen, and extracellular space. Phenotypic associations include increased mutation frequency, heat and cold sensitivity, decreased respiratory growth and starvation resistance, altered lipid particle and mitochondrial morphology, increased colony sectoring, and changes in competitive fitness and chemical resistance.