ACUD — Neurospora crassa

Summary

NCU04230 (ACUD, acu-3) on Neurospora crassa chromosome 5 encodes an isocitrate lyase with isocitrate lyase and methylisocitrate lyase activities, and is localised to the glyoxysome and peroxisome. The gene is associated with the glyoxylate cycle, acetate and fatty acid breakdown, heterotrophy, sporulation, detoxification, and carbohydrate metabolism. It is linked to numerous phenotypes including increased hydrostatic pressure and alkaline pH resistance, increased entry into G0 stationary phase, increased sporulation efficiency and viability, decreased cold sensitivity, apoptosis, and mutation frequency, as well as abnormal cell wall morphology, colony appearance, and vegetative growth. Associations with protein content and altered nutrient and carbon source utilisation have also been noted. Studies of related genes in other species link the family to reduced virulence and altered stationary-phase survival.