SMI1 — Neurospora crassa

Summary

NCU04189 (SMI1, cot-2) in Neurospora crassa encodes a Knr4/Smi1 family protein with protein-binding-bridging and DNA-binding molecular functions. It is associated with fungal-type cell wall beta-glucan anabolism, mitotic division septum assembly, mitotic cell cycle modulation, regulation of fungal-type cell wall biogenesis, cell wall organization, morphogenesis, and DNA-dependent transcription. The gene product localizes to the nucleus, intracellular vesicles, incipient cellular bud site, mating projection tip, cellular bud neck, and cell division site. Studies of related genes in other species link the SMI1 family to cell wall integrity and morphogenesis, though these associations are not yet established in N. crassa.