HSC82 — Neurospora crassa

Summary

NCU04142 (HSC82, hsp80) in Neurospora crassa chromosome 5 encodes an ATP-dependent protein folding chaperone of the Hsp90 family, possessing ATP hydrolase activity and ATP binding. This gene is associated with diverse biological processes including protein folding and stabilization, cellular response to heat, carbon catabolite repression, asexual sporulation, spore formation, filamentous growth, pheromone response, cellulose breakdown, and regulation of apoptosis. It is linked to Box C/D snoRNP assembly, proteasome assembly, multidomain protein assembly, and intracellular steroid hormone receptor signaling. The encoded protein localizes to the hyphal cell wall, cross wall, perinuclear region, mitochondria, plasmalemma, extracellular vesicles, and protein aggregate centers. Phenotypic associations include increased thermotolerance, premature apoptosis, abnormal spore germination, altered cell cycle progression, decreased hypo-osmotic stress resistance, and abnormal flocculation. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.