ERG6 — Neurospora crassa

Summary

NCU04129 (ERG6) on Neurospora crassa chromosome 5 encodes a gamma-tocopherol methyltransferase with sterol 24C methyltransferase activity and SAM-dependent methyltransferase activity. The gene is associated with sterol, ergosterol, ceramide, and hormone anabolism, as well as sterol homeostasis and methylation processes. It has been linked to hypersensitivity and localizes to the endoplasmic reticulum and adiposome. Studies of related genes in other species connect the family to methyltransferase activity (EC 2.1.1.41) and polyketide synthase methyltransferase domains, though these associations are not established for N. crassa.