cmd — Neurospora crassa

Summary

NCU04120 (cmd) on Neurospora crassa chromosome 5 encodes a protein with an EF-hand calcium-binding domain, belonging to the CALM/Myosin/TropC-like family, and is annotated as an enzyme modulator with calcium ion binding activity. The gene is associated with spindle pole body (SPB) organization, circadian rhythm, microtubule cytoskeleton organization, spore germination, calcium signaling, and cell cycle modulation. Its product localizes to the central plaque of the spindle pole body, the myosin II complex, hyphal tips, cell tips, and the cytoplasm. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, though these associations are not yet established in N. crassa.