ERG5 — Neurospora crassa

Summary

NCU04089 (ERG5) in Neurospora crassa encodes a cytochrome P450 monooxygenase, a heme- and iron-binding oxidoreductase that acts on paired donors with incorporation of molecular oxygen. The gene is associated with the biosynthesis of ergosterol, terpenoids, and secondary metabolites including griseofulvin, mycophenolic acid, and cichorine, as well as with hormone anabolism and antibiotic anabolism. ERG5 has been linked to a wide range of phenotypes, including decreased colony size, increased cell death, abnormal autophagy, decreased meiosis, and altered plasma membrane morphology. It is also linked to increased budding, decreased endocytosis, and abnormal vacuolar transport. The encoded protein localises to the endoplasmic reticulum membrane. Related genes in other species are linked to potassium concentration and acid sensitivity.