AAC — Neurospora crassa

Summary

NCU03989 (AAC) on Neurospora crassa chromosome 6 encodes a mitochondrial carrier protein with multiple transmembrane transporter activities, including ATP/ADP exchange, nucleotide transport, coenzyme A transport, and thiamine diphosphate transport. The protein localises to the mitochondrial inner membrane and the MPTP complex, and is associated with mitochondrial biogenesis, protein import, and regulation of mitochondrial membrane permeability. In N. crassa, AAC has been linked to altered nitrogen source utilisation, abnormal G1 cell cycle progression, increased replicative and chronological lifespan, decreased chromosome maintenance, altered chemical compound accumulation, and both increased and decreased competitive fitness and chemical resistance. Studies of related genes in other species connect the family to reduced virulence, decreased oxidative stress resistance, and decreased vegetative growth.