NDH51 — Neurospora crassa

Summary

NCU04044 (NDH51, nuo51) in Neurospora crassa chromosome 6 encodes a protein with NADH-UbQ oxidoreductase and FMN-binding domains that possesses ubiquinone reductase, NAD binding, 4Fe-4S cluster binding, FMN binding, redox activity, and metal binding activities (EC 7.1.1.2). The gene product localises to the mitochondrial inner membrane and is associated with cellular respiration, electron transfer, calcium signalling, cell death, and response to staurosporine. Studies of related genes in other species link the family to NADH dehydrogenase activity, though these associations are not yet established for NDH51 itself.