DBP2 — Neurospora crassa

Summary

NCU04041 (DBP2, also known as NcMAK5) on Neurospora crassa chromosome 6 encodes a DEAD-box RNA helicase with RNA helicase activity, RNA binding, ATP hydrolase activity and ATP binding. The protein localises to the nucleolus and cytosol and is associated with RNA splicing, mRNA processing, ribosome biogenesis and rRNA processing. It is linked to fruiting body formation, sporulation efficiency, vegetative growth, cell cycle progression through G1/S and G2/M phase transitions, mitotic recombination, mating type switching, thermotolerance, gamma ray resistance, chemical resistance, carbon source utilisation, fermentative growth, chromosome segregation and protein/peptide modification. Related genes in other species connect it to oxidative stress response and lethal phenotypes.