PUB1 — Neurospora crassa

Summary

NCU03947, designated NcPUB1, encodes a HECT-type E3 ubiquitin-protein ligase (EC 2.3.2.26) with C2 and WW domains, conferring ubiquitin-protein transferase and ligase activities. In Neurospora crassa, this gene is associated with protein ubiquitination, endocytosis, vacuolar transport, and the multivesicular body pathway for ubiquitin-dependent protein breakdown. It is linked to cell cycle progression, particularly the G2/M phase transition, cytokinesis, and budding patterns. Associations also include nitrogen source utilization, small molecule and peroxisomal transport, hypoosmotic stress resistance, thermotolerance, pheromone response, shmoo formation, and cell fusion. The gene product localizes to the cytoplasm.