CAN1 — Neurospora crassa

Summary

NCU03784 (CAN1) on Neurospora crassa chromosome 5 encodes a cation chloride cotransporter with potassium:chloride symporter activity, belonging to the SLC12 family. The gene is associated with chloride and potassium ion homeostasis, cell volume homeostasis, chloride transmembrane transport, and vacuolar membrane transport. It localises to the vacuolar membrane and vCLAMP. Phenotypic associations include increased cell death, decreased osmotic stress resistance, decreased ionic stress resistance, increased hyperosmotic stress resistance, increased innate thermotolerance, abnormal nucleolar morphology, decreased telomere length, absent biofilm formation under some conditions and increased under others, absent pseudohyphal and invasive growth, increased filamentous growth, decreased silencing, and abnormal actin cytoskeleton morphology. Studies of related genes in other species link the family to haploid insufficiency.