TIM22 — Neurospora crassa

Summary

NCU03798 (TIM22) in Neurospora crassa chromosome 5 encodes a protein with mitochondrion targeting sequence binding, transmembrane transporter activity, and structural molecule activity. The gene is associated with mitochondrial inner membrane protein import and protein import. It localizes to the plasmalemma. Phenotypic associations link TIM22 to mitochondrial transport (both normal and decreased rates), altered mitochondrial genome maintenance, absent anaerobic growth and spore germination, abnormal colony shape, increased cell death, and altered respiratory metabolism. The gene is also associated with petite-negative status, increased hyperosmotic stress resistance, increased biofilm formation, and absent vegetative growth. Related genes include DIC1, SDH3, TIM9, PIC2, TIM12, TIM54, AIM32, TIM10, and TIM18. Related genes in other species are associated with the Tim22 complex and mitochondrial protein import.