CNAB — Neurospora crassa

Summary

NCU03833 (CNAB, cnb-1) on Neurospora crassa chromosome 5 encodes a calcineurin B regulatory subunit containing EF-hand calcium-binding domains. The gene product exhibits calcium-dependent protein serine/threonine phosphatase regulator activity, phosphatase binding and activator activity, and calcium ion binding. CNAB is associated with calcineurin-mediated signaling, calcium ion homeostasis, regulation of phosphorylation, cell morphogenesis, hyphal growth, fungal-type cell wall organization, ER stress response, cellular thermotolerance, pheromone response, conjugation with cellular fusion, and interaction with host. The protein localizes to the calcineurin complex, cytoplasm, cytosol, nucleus, and cell division site. Phenotypic associations include abnormal cell cycle progression, filamentous growth, shmoo formation, cell fusion, nuclear fusion during mating, hyperosmotic stress resistance, pheromone sensitivity, endocytosis, pexophagy, micronucleophagy, and replicative lifespan. Studies of related genes in other species link the calcineurin B family to virulence, pathogenicity, and stress responses including calcium and acid sensitivity.