LYS3 — Neurospora crassa

Summary

NCU03748 (LYS3) on Neurospora crassa chromosome 5 encodes saccharopine reductase, an enzyme with saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity. The gene is associated with lysine anabolism and has been linked to methylation and memory processes. The encoded protein localises to the cytoplasm and cytosol. LYS3 is associated with numerous phenotypes including abnormal mitochondrial transport and morphology, decreased mitophagy, pexophagy and reticulophagy, arrested mitotic cell cycle, abnormal G1 phase progression, absent invasive growth, decreased filamentous, fermentative and anaerobic growth, increased respiratory growth rate, increased innate thermotolerance and cold sensitivity, increased stress and metal resistance, increased replicative and chronological lifespan, and abnormal protein accumulation and RNA modification. Studies of related genes in other species link the family to additional cellular processes.