CDT2 — Neurospora crassa

Summary

NCU03668 (symbol CDT2, preferred name NcCDT2) on Neurospora crassa chromosome 5 encodes a WD domain-containing protein with a WD40-repeat CDT2 adapter domain. The product is associated with protein complex binding and protein binding, bridging, and localises to the Cul4-RING E3 ubiquitin ligase complex and the nucleus. It is associated with protein ubiquitination, the proteasomal pathway, and ubiquitin-dependent proteolysis, as well as NADPH regeneration, regulation of double-strand break repair, regeneration, fermentation, meiotic cell cycle, and cell division. Studies of related genes in other species link the family to Fusarium oxysporum and Verticillium dahliae, but these associations are not established for N. crassa.