vib-1 — Neurospora crassa

Summary

NCU03725, designated vib-1 on Neurospora crassa chromosome 5, encodes a DNA-binding transcription factor belonging to the NDT80/P53-like transcription factor superfamily, characterised by an NDT80 DNA-binding domain and a fungal transcriptional regulator domain. The gene is associated with multiple biological processes including syngamy, mating, meiosis, asexual reproduction, spore germination, programmed cell death, cell death, secretion, heterotrophy, secondary metabolism, regulation of gene expression, and positive regulation of transcription by RNA polymerase II. It is linked to nuclear, cytoplasmic, and chromosomal localisation, as well as the oxidative stress response. Studies of related genes in other species connect the VIB-1 family to virulence modulation, with some relatives showing increased virulence and others unaffected pathogenicity, and to associations with plant pathogens such as Fusarium oxysporum and Verticillium dahliae.