ham-2 — Neurospora crassa

Summary

NCU03727, the Neurospora crassa ham-2 gene on chromosome 5, encodes a protein belonging to the Far11/STRP family, with domains including Far11/STRP_C and Far11/STRP_N. The product has protein binding, bridging molecular function. The gene is associated with cell-cell fusion, membrane fusion, mating, syngamy, chemoattraction, organogenesis, meiosis, cytoskeleton organization, signal transduction, and downregulation of septation initiation signaling. It localises to the SIP complex, nuclear envelope, mitotic spindle pole body, old spindle pole body, fungal-type vacuole, and cytosol. Studies of related genes in other species link the family to pheromone-dependent cell cycle arrest.