ZIP1 — Neurospora crassa

Summary

NCU03536 (ZIP1, cys-3) on Neurospora crassa chromosome 2 encodes a bZIP transcription factor that binds DNA and activates RNA polymerase II transcription. The gene is associated with nitrogen catabolite repression, sulfur metabolism, catabolite repression, and regulation of transcription by RNA polymerase II, including positive regulation. It has also been linked to cellular localization, electron transfer, RNA anabolism, carbohydrate metabolism, cell growth, and cell cycle processes. The product localizes to the nucleus. Related genes in other species, including regulatory protein cys-3 and MetR-like proteins, are linked to calcium sensitivity and associations with fungal pathogens such as Verticillium dahliae and Fusarium oxysporum strains.