RNR1 — Neurospora crassa

Summary

NCU03539, also known as RNR1, un-24, or CDC22, encodes the large subunit of ribonucleoside-diphosphate reductase (RNR), an enzyme with CDP reductase activity that uses thioredoxin disulfide as an acceptor and binds ATP. This Neurospora crassa gene on chromosome 2 is associated with deoxyribonucleotide, dCDP, dTTP, and DNA biosynthesis, as well as CDP metabolism. It is linked to asexual reproduction, mating, meiosis, and programmed cell death. The RNR complex localises to the cytoplasm and cytosol. Phenotypic associations include increased gamma ray and hydrostatic pressure resistance, decreased lifespan, arrested meiosis and cell cycle progression, abnormal telomere length, and absent meiotic recombination. Studies of related genes in other species connect the RNR family to oxidative stress response and acid sensitivity.