frh — Neurospora crassa

Summary

NCU03363 (frh) on Neurospora crassa chromosome 2 encodes an RNA helicase with ATP hydrolase and nucleic acid binding activities, belonging to the SKI2-like and MTR4-like stalk families. The gene is associated with circadian rhythm, rhythmic processes, and multiple RNA surveillance pathways including exosome-mediated degradation, polyadenylation-dependent ncRNA catabolism, siRNA catabolism, and nuclear mRNA surveillance of spliceosomal pre-mRNA splicing. It is linked to heterochromatin island assembly, degradation of meiosis-specific transcripts, rescue of stalled cytosolic ribosomes, and the TRAMP-dependent tRNA surveillance pathway. The encoded protein localizes to the nucleus, nucleolus, cytoplasm, Ski complex, RQT complex, and nuclear bodies. Related genes in other species link the family to the TRAMP complex and the NURS complex.