CWT1 — Neurospora crassa

Summary

NCU03352 (CWT1, also known as aod-2) on Neurospora crassa chromosome 2 encodes a Zn2Cys6 DNA-binding transcription factor with both activator and repressor activities for RNA polymerase II. This nuclear protein is associated with alternative respiration, carbon catabolite repression and activation of transcription, gluconeogenesis, mitochondrial translation, filamentous growth, and cellular responses to starvation and xenobiotic stimuli. The gene has been linked to numerous phenotypes including altered cell cycle progression, increased anaerobic and respiratory growth, abnormal cell wall morphology, increased starvation and osmotic stress resistance, increased vegetative growth, increased sporulation efficiency, and decreased invasive growth and mating response. Studies of related genes in other species connect the family to gluconeogenesis control.