KEX2 — Neurospora crassa

Summary

NCU03219 (KEX2) on Neurospora crassa chromosome 1 encodes a serine-type endopeptidase of the kexin/furin family, a subtilisin-related protease. The gene is associated with protein processing, pheromone processing, and upregulation of conjugation with cellular fusion. Its product localises to the Golgi membrane, trans-Golgi network, and membrane. Phenotypic associations include abnormal mating response, decreased cell fusion, decreased pheromone production, decreased shmoo formation, absent spore germination, sterile phenotype, abnormal filamentous growth, absent protein secretion, absent endocytosis, absent mitophagy, and increased alkaline pH resistance. Studies of related genes in other species link the family to reduced virulence and sensitivity to zinc, acid, and oxidative stress.