prd-4 — Neurospora crassa

Summary

NCU02814 (prd-4) on Neurospora crassa chromosome 1 encodes a protein with a forkhead-associated (FHA) domain and a serine/threonine protein kinase domain, exhibiting calcium/calmodulin-dependent kinase activity, protein kinase A activity, calmodulin binding, and phospholipid binding. The gene is associated with multiple biological processes including sleep, positive regulation of reciprocal meiotic recombination, the meiotic G2/MI DNA replication checkpoint, the pachytene checkpoint, the mitotic DNA damage checkpoint, regulation of invasive growth in response to glucose limitation, positive regulation of pseudohyphal growth, and negative regulation of translation. It localizes to structures such as the linear element, ascus epiplasm, perinuclear space, septin ring, and division septum. Studies of related genes in other species link the family to loss of pathogenicity and lethality.