CCH1 — Neurospora crassa

Summary

NCU02762, designated CCH1 in Neurospora crassa and located on chromosome 1, encodes a high voltage-gated calcium channel subunit (smco-1) containing EF-hand and ion transport domains. The gene product exhibits stretch-activated, monoatomic cation-selective calcium channel activity and calcium ion binding. CCH1 is associated with calcium signaling, the MAPK cascade, FAD transport, ascus development, mating, filamentous growth, and calcium ion import into the cell, and localises to the plasma membrane as part of the voltage-gated calcium channel complex. Phenotypic associations include abnormal cell fusion, absent or decreased recovery from pheromone-induced cell cycle arrest, abnormal Golgi distribution, decreased budding, increased endocytosis, decreased nucleophagy, abnormal shmoo formation, and increased alkaline pH resistance. Studies of related genes in other species link the family to calcium sensitivity, acid sensitivity, and oxidative stress response.