DBP2 — Neurospora crassa

Summary

NCU02696 (DBP2, also known as NcDBP2) encodes a DEAD-box RNA helicase with ATP hydrolase and nucleic acid binding activities, classified as EC 3.6.4.13. The protein is associated with U1 and U2 snRNP binding, localizes to the nucleus and major prespliceosome, and is linked to RNA splicing, mRNA processing, ribosome biogenesis, and fruiting body formation. Phenotypic associations include abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, altered cell cycle progression (including increased G1/S transition rate and delayed anaphase), delayed vegetative and exponential growth, increased thermotolerance and gamma ray resistance, increased fermentative growth, and altered carbon source utilization. Related genes in other species are linked to oxidative stress response.